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2ktu
From Proteopedia
(Difference between revisions)
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==Human eRF1 C-domain, "closed" conformer== | ==Human eRF1 C-domain, "closed" conformer== | ||
| - | <StructureSection load='2ktu' size='340' side='right' caption='[[2ktu]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''> | + | <StructureSection load='2ktu' size='340' side='right'caption='[[2ktu]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ktu]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ktu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KTU FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hst|2hst]], [[1dt9|1dt9]], [[2ktv|2ktv]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hst|2hst]], [[1dt9|1dt9]], [[2ktv|2ktv]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETF1, ERF1, RF1, SUP45L1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETF1, ERF1, RF1, SUP45L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ktu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktu OCA], [https://pdbe.org/2ktu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ktu RCSB], [https://www.ebi.ac.uk/pdbsum/2ktu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Birdsall, B]] | [[Category: Birdsall, B]] | ||
[[Category: Mantsyzov, A B]] | [[Category: Mantsyzov, A B]] | ||
Revision as of 07:32, 14 April 2021
Human eRF1 C-domain, "closed" conformer
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