2ogb

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[[Image:2ogb.gif|left|200px]]
[[Image:2ogb.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ogb |SIZE=350|CAPTION= <scene name='initialview01'>2ogb</scene>, resolution 1.950&Aring;
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The line below this paragraph, containing "STRUCTURE_2ogb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Rnf41 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2ogb| PDB=2ogb | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ogb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ogb OCA], [http://www.ebi.ac.uk/pdbsum/2ogb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ogb RCSB]</span>
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}}
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'''Crystal structure of the C-terminal domain of mouse Nrdp1'''
'''Crystal structure of the C-terminal domain of mouse Nrdp1'''
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[[Category: Bouyain, S.]]
[[Category: Bouyain, S.]]
[[Category: Leahy, D J.]]
[[Category: Leahy, D J.]]
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[[Category: e3 ubiquitin ligase]]
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[[Category: E3 ubiquitin ligase]]
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[[Category: receptor-binding region]]
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[[Category: Receptor-binding region]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:51:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:17:28 2008''
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Revision as of 07:51, 4 May 2008

Image:2ogb.gif

Template:STRUCTURE 2ogb

Crystal structure of the C-terminal domain of mouse Nrdp1


Overview

The E3 ubiquitin ligase neuregulin receptor degrading protein 1 (Nrdp1) mediates the ligand-independent degradation of the epidermal growth factor receptor family member ErbB3/HER3. By regulating cellular levels of ErbB3, Nrdp1 influences ErbB3-mediated signaling, which is essential for normal vertebrate development. Nrdp1 belongs to the tripartite or RBCC (RING, B-box, coiled-coil) family of ubiquitin ligases in which the RING domain is responsible for ubiquitin ligation and a variable C-terminal region mediates substrate recognition. We report here the 1.95 A crystal structure of the C-terminal domain of Nrdp1 and show that this domain is sufficient to mediate ErbB3 binding. Furthermore, we have used site-directed mutagenesis to map regions of the Nrdp1 surface that are important for interacting with ErbB3 and mediating its degradation in transfected cells. The ErbB3-binding site localizes to a region of Nrdp1 that is conserved from invertebrates to vertebrates, in contrast to ErbB3, which is only found in vertebrates. This observation suggests that Nrdp1 uses a common binding site to recognize its targets in different species.

About this Structure

2OGB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3., Bouyain S, Leahy DJ, Protein Sci. 2007 Apr;16(4):654-61. PMID:17384230 Page seeded by OCA on Sun May 4 10:51:05 2008

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