2ogp

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ogp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ogp OCA], [http://www.ebi.ac.uk/pdbsum/2ogp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ogp RCSB]</span>
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'''Solution structure of the second PDZ domain of Par-3'''
'''Solution structure of the second PDZ domain of Par-3'''
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[[Category: Wu, H.]]
[[Category: Wu, H.]]
[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
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[[Category: cell polarity]]
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[[Category: Cell polarity]]
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[[Category: par-3]]
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[[Category: Par-3]]
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[[Category: pdz domain]]
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[[Category: Pdz domain]]
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[[Category: signaling protein]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:52:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:17:34 2008''
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Revision as of 07:52, 4 May 2008

Image:2ogp.jpg

Template:STRUCTURE 2ogp

Solution structure of the second PDZ domain of Par-3


Overview

Multiple PDZ domain scaffold protein Par-3 and phosphoinositides (PIPs) are required for polarity in diverse cell types. We show that the second PDZ domain of Par-3 binds to phosphatidylinositol (PI) lipid membranes with high affinity. We further demonstrate that a large subset of PDZ domains in mammalian genomes are capable of binding to PI lipid membranes, indicating that lipid binding is the second most prevalent interaction mode of PDZ domains known to date. The biochemical and structural basis of Par-3 PDZ2-mediated membrane interaction is characterized in detail. The membrane binding capacity of Par-3 PDZ2 is critical for epithelial cell polarization. Interestingly, the lipid phosphatase PTEN directly binds to the third PDZ domain of Par-3. The concatenation of the PIP-binding PDZ2 and the lipid phosphatase PTEN-binding PDZ3 endows Par-3 as an ideal scaffold protein for integrating PIP signaling events during cellular polarization.

About this Structure

2OGP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

PDZ domains of Par-3 as potential phosphoinositide signaling integrators., Wu H, Feng W, Chen J, Chan LN, Huang S, Zhang M, Mol Cell. 2007 Dec 14;28(5):886-98. PMID:18082612 Page seeded by OCA on Sun May 4 10:52:38 2008

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