6h62
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==QTRT1, the catalytic subunit of murine tRNA-Guanine Transglycosylase== | |
| - | + | <StructureSection load='6h62' size='340' side='right'caption='[[6h62]], [[Resolution|resolution]] 2.68Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6h62]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H62 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h62 OCA], [http://pdbe.org/6h62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h62 RCSB], [http://www.ebi.ac.uk/pdbsum/6h62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h62 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TGT_MOUSE TGT_MOUSE]] Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:19414587, PubMed:29862811). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity).[HAMAP-Rule:MF_03218]<ref>PMID:19414587</ref> <ref>PMID:29862811</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Behrens, C]] | ||
| + | [[Category: Heine, A]] | ||
[[Category: Reuter, K]] | [[Category: Reuter, K]] | ||
| - | [[Category: | + | [[Category: Tim barrel]] |
| - | [[Category: | + | [[Category: Transferase]] |
| + | [[Category: Transglycosylase]] | ||
Revision as of 16:28, 14 August 2019
QTRT1, the catalytic subunit of murine tRNA-Guanine Transglycosylase
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