6f45
From Proteopedia
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<StructureSection load='6f45' size='340' side='right' caption='[[6f45]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='6f45' size='340' side='right' caption='[[6f45]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6f45]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F45 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6f45]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_bacteriophage_s16 Salmonella bacteriophage s16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F45 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f45 OCA], [http://pdbe.org/6f45 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f45 RCSB], [http://www.ebi.ac.uk/pdbsum/6f45 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f45 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f45 OCA], [http://pdbe.org/6f45 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f45 RCSB], [http://www.ebi.ac.uk/pdbsum/6f45 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f45 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The ability of phages to infect specific bacteria has led to their exploitation as bio-tools for bacterial remediation and detection. Many phages recognize bacterial hosts via adhesin tips of their long tail fibers (LTFs). Adhesin sequence plasticity modulates receptor specificity, and thus primarily defines a phage's host range. Here we present the crystal structure of an adhesin (gp38) attached to a trimeric beta-helical tip (gp37) from the Salmonella phage S16 LTF. Gp38 contains rare polyglycine type II helices folded into a packed lattice, herein designated "PGII sandwich." Sequence variability within the domain is limited to surface-exposed helices and distal loops that form putative receptor-binding sites. In silico analyses revealed a prevalence of the adhesin architecture among T-even phages, excluding the archetypal T4 phage. Overall, S16 LTF provides a valuable model for understanding binding mechanisms of phage adhesins, and for engineering of phage adhesins with expandable or modulated host ranges. | ||
| + | |||
| + | Salmonella Phage S16 Tail Fiber Adhesin Features a Rare Polyglycine Rich Domain for Host Recognition.,Dunne M, Denyes JM, Arndt H, Loessner MJ, Leiman PG, Klumpp J Structure. 2018 Aug 16. pii: S0969-2126(18)30263-6. doi:, 10.1016/j.str.2018.07.017. PMID:30244968<ref>PMID:30244968</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6f45" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Salmonella bacteriophage s16]] | ||
[[Category: Dunne, M]] | [[Category: Dunne, M]] | ||
[[Category: Klumpp, J]] | [[Category: Klumpp, J]] | ||
Revision as of 08:50, 3 October 2018
Crystal structure of the gp37-gp38 adhesin tip complex of the bacteriophage S16 long tail fiber
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