2ojt

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[[Image:2ojt.jpg|left|200px]]
[[Image:2ojt.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ojt |SIZE=350|CAPTION= <scene name='initialview01'>2ojt</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_2ojt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=UBA:(S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE'>UBA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= Grik1, Glur5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_2ojt| PDB=2ojt | SCENE= }}
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|RELATEDENTRY=[[2f34|2F34]], [[2f36|2F36]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ojt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ojt OCA], [http://www.ebi.ac.uk/pdbsum/2ojt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ojt RCSB]</span>
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'''Structure and mechanism of kainate receptor modulation by anions'''
'''Structure and mechanism of kainate receptor modulation by anions'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Mayer, M L.]]
[[Category: Mayer, M L.]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:03:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:18:48 2008''
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Revision as of 08:03, 4 May 2008

Image:2ojt.jpg

Template:STRUCTURE 2ojt

Structure and mechanism of kainate receptor modulation by anions


Overview

L-glutamate, the major excitatory neurotransmitter in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which are named AMPA, kainate, and NMDA receptors. In common with many signal transduction proteins, glutamate receptors are modulated by ions and small molecules, including Ca(2+), Mg(2+), Zn(2+), protons, polyamines, and steroids. Strikingly, the activation of kainate receptors by glutamate requires the presence of both Na(+) and Cl(-) in the extracellular solution, and in the absence of these ions, receptor activity is abolished. Here, we identify the site and mechanism of action of anions. Surprisingly, we find that Cl(-) ions are essential structural components of kainate receptors. Cl(-) ions bind in a cavity formed at the interface between subunits in a dimer pair. In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously.

About this Structure

2OJT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of kainate receptor modulation by anions., Plested AJ, Mayer ML, Neuron. 2007 Mar 15;53(6):829-41. PMID:17359918 Page seeded by OCA on Sun May 4 11:03:34 2008

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