2l9r
From Proteopedia
(Difference between revisions)
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==Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A== | ==Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A== | ||
| - | <StructureSection load='2l9r' size='340' side='right' caption='[[2l9r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2l9r' size='340' side='right'caption='[[2l9r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l9r]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9R FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NKX3-1, NKX3.1, NKX3A ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NKX3-1, NKX3.1, NKX3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9r OCA], [https://pdbe.org/2l9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9r RCSB], [https://www.ebi.ac.uk/pdbsum/2l9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9r ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NKX31_HUMAN NKX31_HUMAN]] Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.<ref>PMID:19462257</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Acton, T B]] | [[Category: Acton, T B]] | ||
[[Category: Ciccosanti, C]] | [[Category: Ciccosanti, C]] | ||
Revision as of 07:38, 14 April 2021
Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A
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Categories: Human | Large Structures | Acton, T B | Ciccosanti, C | Everett, J K | Hamilton, K | Huang, Y J | Lee, H W | Liu, G | Montelione, G T | Structural genomic | Wang, H B | Xiao, R | Methods development | Nesg | PSI, Protein structure initiative | Psi-biology | Transcription | Transcription factor
