6dks
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Rbpj-SHARP-DNA Repressor Complex== | |
| - | + | <StructureSection load='6dks' size='340' side='right' caption='[[6dks]], [[Resolution|resolution]] 2.78Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6dks]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DKS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dks OCA], [http://pdbe.org/6dks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dks RCSB], [http://www.ebi.ac.uk/pdbsum/6dks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dks ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). [[http://www.uniprot.org/uniprot/SUH_MOUSE SUH_MOUSE]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.<ref>PMID:7566092</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kovall, R A]] | ||
| + | [[Category: VanderWielen, B D]] | ||
[[Category: Yuan, Z]] | [[Category: Yuan, Z]] | ||
| - | [[Category: | + | [[Category: Csl]] |
| - | [[Category: | + | [[Category: Mint]] |
| + | [[Category: Notch signaling]] | ||
| + | [[Category: Rbpjk]] | ||
| + | [[Category: Sharp]] | ||
| + | [[Category: Transcription-dna complex]] | ||
| + | [[Category: Transport-dna binding-dna complex]] | ||
Revision as of 06:09, 2 January 2019
Structure of the Rbpj-SHARP-DNA Repressor Complex
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