6dz4

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'''Unreleased structure'''
 
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The entry 6dz4 is ON HOLD until Paper Publication
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==Crystal structure of Salmonella typhimurium Tryptophan Synthase with sodium ion at the metal coordination site and [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine (PLS) at the beta-site.==
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<StructureSection load='6dz4' size='340' side='right'caption='[[6dz4]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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Authors: Hilario, E., Dunn, M.F., Mueller, L.J., Fan, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6dz4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZ4 FirstGlance]. <br>
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Description: Crystal structure of Salmonella typhimurium Tryptophan Synthase with sodium ion at the metal coordination site and [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine (PLS) at the beta-site.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLS:[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE'>PLS</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hn4|4hn4]], [[4hpx|4hpx]]</td></tr>
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[[Category: Dunn, M.F]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dz4 OCA], [http://pdbe.org/6dz4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dz4 RCSB], [http://www.ebi.ac.uk/pdbsum/6dz4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dz4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Tryptophan synthase]]
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[[Category: Dunn, M F]]
[[Category: Fan, L]]
[[Category: Fan, L]]
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[[Category: Mueller, L.J]]
 
[[Category: Hilario, E]]
[[Category: Hilario, E]]
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[[Category: Mueller, L J]]
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[[Category: F9f]]
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[[Category: Lyase]]
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[[Category: Lyase inhibitor]]
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[[Category: Pl]]
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[[Category: Salmonella typhimurium]]
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[[Category: Sodium ion]]

Revision as of 05:40, 10 July 2019

Crystal structure of Salmonella typhimurium Tryptophan Synthase with sodium ion at the metal coordination site and [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine (PLS) at the beta-site.

PDB ID 6dz4

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OCA

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