6e7d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b== | |
| - | + | <StructureSection load='6e7d' size='340' side='right' caption='[[6e7d]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6e7d]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E7D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7d OCA], [http://pdbe.org/6e7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e7d RCSB], [http://www.ebi.ac.uk/pdbsum/6e7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7d ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CLC2D_MOUSE CLC2D_MOUSE]] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).<ref>PMID:11278931</ref> <ref>PMID:12374791</ref> <ref>PMID:14990792</ref> <ref>PMID:15123656</ref> <ref>PMID:16751398</ref> [[http://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE]] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Balaji, G R]] | ||
| + | [[Category: Berry, R]] | ||
| + | [[Category: Rossjohn, J]] | ||
| + | [[Category: C-type lectin related ligand]] | ||
| + | [[Category: Immune complex]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Innate immunity]] | ||
| + | [[Category: Natural killer cell receptor]] | ||
Revision as of 05:54, 24 October 2018
Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b
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