2oox

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[[Image:2oox.gif|left|200px]]
[[Image:2oox.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2oox |SIZE=350|CAPTION= <scene name='initialview01'>2oox</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2oox", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ssp2, SPCC74.03c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe]), SPCC1919.03c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe]), SPAC1556.08c, SPAC1F12.01c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])
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-->
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|DOMAIN=
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{{STRUCTURE_2oox| PDB=2oox | SCENE= }}
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|RELATEDENTRY=[[2ooy|2OOY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oox OCA], [http://www.ebi.ac.uk/pdbsum/2oox PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oox RCSB]</span>
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}}
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'''Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP'''
'''Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP'''
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[[Category: Shapiro, L.]]
[[Category: Shapiro, L.]]
[[Category: Townley, R.]]
[[Category: Townley, R.]]
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[[Category: amp]]
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[[Category: Amp]]
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[[Category: ampk]]
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[[Category: Ampk]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: kinase]]
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[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:21:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:57 2008''
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Revision as of 08:21, 4 May 2008

Image:2oox.gif

Template:STRUCTURE 2oox

Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP


Overview

The 5'-AMP (adenosine monophosphate)-activated protein kinase (AMPK) coordinates metabolic function with energy availability by responding to changes in intracellular ATP (adenosine triphosphate) and AMP concentrations. Here, we report crystal structures at 2.9 and 2.6 A resolution for ATP- and AMP-bound forms of a core alphabetagamma adenylate-binding domain from the fission yeast AMPK homolog. ATP and AMP bind competitively to a single site in the gamma subunit, with their respective phosphate groups positioned near function-impairing mutants. Unexpectedly, ATP binds without counterions, amplifying its electrostatic effects on a critical regulatory region where all three subunits converge.

About this Structure

2OOX is a Protein complex structure of sequences from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase., Townley R, Shapiro L, Science. 2007 Mar 23;315(5819):1726-9. Epub 2007 Feb 8. PMID:17289942 Page seeded by OCA on Sun May 4 11:21:19 2008

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