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6gzd
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human CSNK1A1 with A86== | |
| - | + | <StructureSection load='6gzd' size='340' side='right' caption='[[6gzd]], [[Resolution|resolution]] 2.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gzd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LCI:[4-[[4-[5-(cyclopropylmethyl)-1-methyl-pyrazol-4-yl]-5-fluoranyl-pyrimidin-2-yl]amino]cyclohexyl]azanium'>LCI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gzd OCA], [http://pdbe.org/6gzd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gzd RCSB], [http://www.ebi.ac.uk/pdbsum/6gzd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gzd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KC1A_HUMAN KC1A_HUMAN]] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).<ref>PMID:11955436</ref> <ref>PMID:1409656</ref> <ref>PMID:18305108</ref> <ref>PMID:23902688</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Ben-Neriah, Y]] | ||
[[Category: Fink, A]] | [[Category: Fink, A]] | ||
| - | [[Category: | + | [[Category: Minzel, W]] |
[[Category: Snir-Alkalay, I]] | [[Category: Snir-Alkalay, I]] | ||
| - | [[Category: Minzel, W]] | ||
[[Category: Vacca, J]] | [[Category: Vacca, J]] | ||
[[Category: Venkatachalam, A]] | [[Category: Venkatachalam, A]] | ||
| + | [[Category: Casein kinase]] | ||
| + | [[Category: Ckia]] | ||
| + | [[Category: Kinase inhibitor]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:34, 29 August 2018
Crystal structure of Human CSNK1A1 with A86
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