6h5t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Intersectin SH3A short isoform== | |
| - | + | <StructureSection load='6h5t' size='340' side='right' caption='[[6h5t]], [[Resolution|resolution]] 1.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6h5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H5T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5t OCA], [http://pdbe.org/6h5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5t RCSB], [http://www.ebi.ac.uk/pdbsum/6h5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5t ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Driller, J H]] | ||
| + | [[Category: Freund, C]] | ||
| + | [[Category: Gerth, F]] | ||
| + | [[Category: Loll, B]] | ||
| + | [[Category: Wahl, M C]] | ||
| + | [[Category: Endocytosis]] | ||
| + | [[Category: Intersectin 1]] | ||
| + | [[Category: Sh3 domain]] | ||
| + | [[Category: Splice isoform]] | ||
Revision as of 15:21, 27 February 2019
Intersectin SH3A short isoform
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Categories: Driller, J H | Freund, C | Gerth, F | Loll, B | Wahl, M C | Endocytosis | Intersectin 1 | Sh3 domain | Splice isoform
