6alk
From Proteopedia
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<StructureSection load='6alk' size='340' side='right' caption='[[6alk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='6alk' size='340' side='right' caption='[[6alk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6alk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ALK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ALK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6alk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Beechnut Beechnut]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ALK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ALK FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6alk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6alk OCA], [http://pdbe.org/6alk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6alk RCSB], [http://www.ebi.ac.uk/pdbsum/6alk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6alk ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6alk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6alk OCA], [http://pdbe.org/6alk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6alk RCSB], [http://www.ebi.ac.uk/pdbsum/6alk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6alk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Fag s 1 is a member of the Pathogen Related protein family 10 (PR-10) and can elicit cross-reaction with IgE antibodies produced against the birch pollen allergen Bet v 1. The Nuclear Magnetic Resonance (NMR) structure of Fag s 1 is presented along with its dynamic properties. It shares 66% identity with Bet v 1 and exhibits the expected three alpha-helices and seven beta-sheets arranged as a semi-beta barrel and exposing the residues mapped as the Bet v 1 IgE epitope. The structural dynamics of Fag s 1 were monitored on the fast and intermediate timescales, using relaxation rates. The complex dynamics of Fag s 1 are closely related to the internal cavity, and they modulate IgE and ligand binding. | ||
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| + | Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1.,Moraes AH, Asam C, Almeida FCL, Wallner M, Ferreira F, Valente AP Sci Rep. 2018 Jul 12;8(1):10512. doi: 10.1038/s41598-018-28358-1. PMID:30002383<ref>PMID:30002383</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6alk" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Beechnut]] | ||
[[Category: Almeida, F C.L]] | [[Category: Almeida, F C.L]] | ||
[[Category: Asam, A]] | [[Category: Asam, A]] | ||
Revision as of 15:53, 27 February 2019
NMR solution structure of the major beech pollen allergen Fag s 1
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