2ot8

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[[Image:2ot8.gif|left|200px]]
[[Image:2ot8.gif|left|200px]]
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{{Structure
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|PDB= 2ot8 |SIZE=350|CAPTION= <scene name='initialview01'>2ot8</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_2ot8", creates the "Structure Box" on the page.
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|SITE=
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|GENE= TNPO1, KPNB2, MIP1, TRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HNRPM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2ot8| PDB=2ot8 | SCENE= }}
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|RELATEDENTRY=[[1qbk|1qbk]], [[2h4m|2h4m]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ot8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ot8 OCA], [http://www.ebi.ac.uk/pdbsum/2ot8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ot8 RCSB]</span>
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'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
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[[Category: Cansizoglu, A E.]]
[[Category: Cansizoglu, A E.]]
[[Category: Chook, Y M.]]
[[Category: Chook, Y M.]]
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[[Category: heat repeat]]
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[[Category: Heat repeat]]
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[[Category: karyopherin]]
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[[Category: Karyopherin]]
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[[Category: nuclear import complex]]
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[[Category: Nuclear import complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:36:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:43 2008''
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Revision as of 08:36, 4 May 2008

Image:2ot8.gif

Template:STRUCTURE 2ot8

Karyopherin Beta2/Transportin-hnRNPM NLS Complex


Overview

Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.

About this Structure

2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768 Page seeded by OCA on Sun May 4 11:36:28 2008

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