This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2mh3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1==
==NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1==
-
<StructureSection load='2mh3' size='340' side='right' caption='[[2mh3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2mh3' size='340' side='right'caption='[[2mh3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2mh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MH3 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2mh3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MH3 FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HES1, BHLHB39, HL, HRY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HES1, BHLHB39, HL, HRY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh3 OCA], [http://pdbe.org/2mh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mh3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mh3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mh3 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh3 OCA], [https://pdbe.org/2mh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mh3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mh3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN]] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref>
+
[[https://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN]] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 23:
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
 +
[[Category: Large Structures]]
[[Category: Boelens, R]]
[[Category: Boelens, R]]
[[Category: Coglievina, M]]
[[Category: Coglievina, M]]

Revision as of 10:10, 26 May 2021

NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1

PDB ID 2mh3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mh3"
Personal tools