This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2m85
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==PHD Domain from Human SHPRH== | ==PHD Domain from Human SHPRH== | ||
| - | <StructureSection load='2m85' size='340' side='right' caption='[[2m85]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2m85' size='340' side='right'caption='[[2m85]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2m85]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2m85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M85 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fui|2fui]], [[1xwh|1xwh]], [[1wep|1wep]], [[2jmi|2jmi]], [[2vpd|2vpd]], [[2rsd|2rsd]], [[1x4i|1x4i]], [[2k16|2k16]], [[2k1j|2k1j]], [[2kkg|2kkg]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fui|2fui]], [[1xwh|1xwh]], [[1wep|1wep]], [[2jmi|2jmi]], [[2vpd|2vpd]], [[2rsd|2rsd]], [[1x4i|1x4i]], [[2k16|2k16]], [[2k1j|2k1j]], [[2kkg|2kkg]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SHPRH, KIAA2023 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SHPRH, KIAA2023 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m85 OCA], [https://pdbe.org/2m85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m85 RCSB], [https://www.ebi.ac.uk/pdbsum/2m85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m85 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN]] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref> |
==See Also== | ==See Also== | ||
| - | *[[Exosome|Exosome]] | + | *[[Exosome 3D structures|Exosome 3D structures]] |
| - | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 20: | Line 20: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Almeida, F C.L]] | [[Category: Almeida, F C.L]] | ||
[[Category: Bezsonova, I]] | [[Category: Bezsonova, I]] | ||
Revision as of 11:01, 19 May 2021
PHD Domain from Human SHPRH
| |||||||||||
Categories: Human | Large Structures | Almeida, F C.L | Bezsonova, I | Korzhnev, D M | Machado, L E.S F | Pozhidaeva, A | Pustovalova, Y | Helicase | Histone linker | Hydrolase | Ligase | Phd finger | Ring finger | Shprh | Snf2
