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6cpi

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Revision as of 07:50, 12 September 2018

Solution structure of SH3 domain from Shank1

Structural highlights

6cpi is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	SHANK1 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SHAN1_HUMAN] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Publication Abstract from PubMed

Shank proteins are abundant scaffold proteins in the postsynaptic density (PSD) region of brain synapses. Mutations in Shank proteins are associated with autism, schizophrenia, and Alzheimer's disease. To gain insights into Shank protein interactions at the PSD, we determined the solution structures of the src homology 3 (SH3) domains of all three mammalian Shank proteins. Our findings indicate that they have identical and typical SH3 folding motifs, but unusual target-binding pockets. An investigation into the interaction between the Shank SH3 domains and the proline-rich region of the Cav1.3 calcium channel revealed an atypical interaction in which the highly acidic specificity binding pocket of the SH3 domains binds to a Cav1.3 region containing a cluster of three Arg residues. Our study provides insights into Shank SH3-mediated interactions.

Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels.,Ishida H, Skorobogatov A, Yamniuk AP, Vogel HJ FEBS Lett. 2018 Jul 29. doi: 10.1002/1873-3468.13209. PMID:30058071^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ishida H, Skorobogatov A, Yamniuk AP, Vogel HJ. Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels. FEBS Lett. 2018 Jul 29. doi: 10.1002/1873-3468.13209. PMID:30058071 doi:http://dx.doi.org/10.1002/1873-3468.13209

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6cpi"

@@ Line 3: / Line 3: @@
 <StructureSection load='6cpi' size='340' side='right' caption='[[6cpi]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6cpi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CPI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6cpi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CPI FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cpi OCA], [http://pdbe.org/6cpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cpi RCSB], [http://www.ebi.ac.uk/pdbsum/6cpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cpi ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SHANK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cpi OCA], [http://pdbe.org/6cpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cpi RCSB], [http://www.ebi.ac.uk/pdbsum/6cpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cpi ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Human]]
 [[Category: Ishida, H]]
 [[Category: Vogel, H J]]

6cpi

From Proteopedia

Revision as of 07:50, 12 September 2018

Solution structure of SH3 domain from Shank1

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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