This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2na6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Transmembrane domain of mouse Fas/CD95 death receptor==
==Transmembrane domain of mouse Fas/CD95 death receptor==
-
<StructureSection load='2na6' size='340' side='right' caption='[[2na6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+
<StructureSection load='2na6' size='340' side='right'caption='[[2na6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2na6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NA6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2na6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NA6 FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2na7|2na7]]</td></tr>
+
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2na7|2na7]]</div></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fas, Apt1, Tnfrsf6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fas, Apt1, Tnfrsf6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2na6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na6 OCA], [http://pdbe.org/2na6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2na6 RCSB], [http://www.ebi.ac.uk/pdbsum/2na6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2na6 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2na6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na6 OCA], [https://pdbe.org/2na6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2na6 RCSB], [https://www.ebi.ac.uk/pdbsum/2na6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2na6 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.
+
[[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
+
[[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Chou, J J]]
[[Category: Chou, J J]]

Revision as of 15:43, 8 June 2021

Transmembrane domain of mouse Fas/CD95 death receptor

PDB ID 2na6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2na6"
Personal tools