2n7k
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Unveiling the structural determinants of KIAA0323 binding preference for NEDD8== | ==Unveiling the structural determinants of KIAA0323 binding preference for NEDD8== | ||
| - | <StructureSection load='2n7k' size='340' side='right' caption='[[2n7k]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''> | + | <StructureSection load='2n7k' size='340' side='right'caption='[[2n7k]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2n7k]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2n7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7K FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NEDD8 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NEDD8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KHNYN, KIAA0323 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7k OCA], [https://pdbe.org/2n7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7k RCSB], [https://www.ebi.ac.uk/pdbsum/2n7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7k ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NEDD8_HUMAN NEDD8_HUMAN]] Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.<ref>PMID:10318914</ref> <ref>PMID:10597293</ref> <ref>PMID:11953428</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 14: | Line 14: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Castagnoli, L]] | [[Category: Castagnoli, L]] | ||
[[Category: Cesareni, G]] | [[Category: Cesareni, G]] | ||
Revision as of 15:41, 8 June 2021
Unveiling the structural determinants of KIAA0323 binding preference for NEDD8
| |||||||||||
