This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2p1l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2p1l.gif|left|200px]]
[[Image:2p1l.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2p1l |SIZE=350|CAPTION= <scene name='initialview01'>2p1l</scene>, resolution 2.50&Aring;
+
The line below this paragraph, containing "STRUCTURE_2p1l", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BECN1, GT197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2p1l| PDB=2p1l | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1l OCA], [http://www.ebi.ac.uk/pdbsum/2p1l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p1l RCSB]</span>
+
-
}}
+
'''Structure of the Bcl-XL:Beclin 1 complex'''
'''Structure of the Bcl-XL:Beclin 1 complex'''
Line 28: Line 25:
[[Category: Oberstein, A L.]]
[[Category: Oberstein, A L.]]
[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
-
[[Category: apoptosis]]
+
[[Category: Apoptosis]]
-
[[Category: autophagy]]
+
[[Category: Autophagy]]
-
[[Category: bcl]]
+
[[Category: Bcl]]
-
[[Category: beclin]]
+
[[Category: Beclin]]
-
[[Category: bh3 domain]]
+
[[Category: Bh3 domain]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:08:53 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:27:04 2008''
+

Revision as of 09:08, 4 May 2008

Image:2p1l.gif

Template:STRUCTURE 2p1l

Structure of the Bcl-XL:Beclin 1 complex


Overview

Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family members Bcl-2 and/or Bcl-X(L). However, the molecular basis for this interaction remains enigmatic. Here we report that Beclin 1 contains a conserved BH3 domain, which is both necessary and sufficient for its interaction with Bcl-X(L). We also report the crystal structure of a Beclin BH3 peptide in complex with Bcl-X(L) at 2.5A resolution. Reminiscent of previously determined Bcl-X(L)-BH3 structures, the amphipathic BH3 helix of Beclin 1 bound to a conserved hydrophobic groove of Bcl-X(L). These results define Beclin 1 as a novel BH3-only protein, implying that Beclin 1 may have a direct role in initiating apoptotic signaling. We propose that this putative apoptotic function may be linked to the ability of Beclin 1 to suppress tumor formation in mammals.

About this Structure

2P1L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein., Oberstein A, Jeffrey PD, Shi Y, J Biol Chem. 2007 Apr 27;282(17):13123-32. Epub 2007 Mar 2. PMID:17337444 Page seeded by OCA on Sun May 4 12:08:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p1l"
Personal tools