2p24

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[[Image:2p24.jpg|left|200px]]
[[Image:2p24.jpg|left|200px]]
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{{Structure
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|PDB= 2p24 |SIZE=350|CAPTION= <scene name='initialview01'>2p24</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_2p24", creates the "Structure Box" on the page.
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|SITE=
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|GENE= H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), I-Au ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2p24| PDB=2p24 | SCENE= }}
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|RELATEDENTRY=[[2p1y|2P1Y]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p24 OCA], [http://www.ebi.ac.uk/pdbsum/2p24 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p24 RCSB]</span>
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'''I-Au/MBP125-135'''
'''I-Au/MBP125-135'''
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[[Category: McBeth, C.]]
[[Category: McBeth, C.]]
[[Category: Strong, R K.]]
[[Category: Strong, R K.]]
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[[Category: i-au]]
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[[Category: I-au]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: immunoglobulin fold]]
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[[Category: Immunoglobulin fold]]
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[[Category: mbp]]
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[[Category: Mbp]]
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[[Category: mhc]]
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[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:10:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:27:23 2008''
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Revision as of 09:10, 4 May 2008

Image:2p24.jpg

Template:STRUCTURE 2p24

I-Au/MBP125-135


Overview

We report crystal structures of a negatively selected T cell receptor (TCR) that recognizes two I-A(u)-restricted myelin basic protein peptides and one of its peptide/major histocompatibility complex (pMHC) ligands. Unusual complementarity-determining region (CDR) structural features revealed by our analyses identify a previously unrecognized mechanism by which the highly variable CDR3 regions define ligand specificity. In addition to the pMHC contact residues contributed by CDR3, the CDR3 residues buried deep within the V alpha/V beta interface exert indirect effects on recognition by influencing the V alpha/V beta interdomain angle. This phenomenon represents an additional mechanism for increasing the potential diversity of the TCR repertoire. Both the direct and indirect effects exerted by CDR residues can impact global TCR/MHC docking. Analysis of the available TCR structures in light of these results highlights the significance of the V alpha/V beta interdomain angle in determining specificity and indicates that TCR/pMHC interface features do not distinguish autoimmune from non-autoimmune class II-restricted TCRs.

About this Structure

2P24 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

A new twist in TCR diversity revealed by a forbidden alphabeta TCR., McBeth C, Seamons A, Pizarro JC, Fleishman SJ, Baker D, Kortemme T, Goverman JM, Strong RK, J Mol Biol. 2008 Feb 1;375(5):1306-19. Epub 2007 Nov 17. PMID:18155234 Page seeded by OCA on Sun May 4 12:10:57 2008

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