This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Nuclear receptor coactivator
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
*'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | *'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | ||
== Structural highlights == | == Structural highlights == | ||
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/7'>NCOA/STAT6 transactivator domain LXXLL peptide interactions</scene>. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/8'>1st Iod coordination site</scene>. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/9'>2nd Iod coordination site</scene>. Water molecules are shown as red spheres. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/10'>3th and 4th Iod coordination sites</scene>. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/11'>5th Iod coordination site</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 14:10, 23 July 2019
| |||||||||||
3D structures of nuclear receptor coactivator
1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
References
- ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
