2p59

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[[Image:2p59.jpg|left|200px]]
[[Image:2p59.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2p59 |SIZE=350|CAPTION= <scene name='initialview01'>2p59</scene>, resolution 2.900&Aring;
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The line below this paragraph, containing "STRUCTURE_2p59", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gg4+Binding+Site+For+Residue+B+1208'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GG4:(2S,3AS,7AS)-1-[(2S)-2-{[(2S)-2-CYCLOHEXYL-2-({[(2R)-4-NITRO-2H-PYRROL-2-YL]CARBONYL}AMINO)ACETYL]AMINO}-3,3-DIMETHYLBUTANOYL]-N-{(1S)-1-[(1R)-2-(CYCLOPROPYLAMINO)-1-HYDROXY-2-OXOETHYL]BUTYL}OCTAHYDRO-1H-INDOLE-2-CARBOXAMIDE'>GG4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NS3 protease domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
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-->
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|DOMAIN=
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{{STRUCTURE_2p59| PDB=2p59 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p59 OCA], [http://www.ebi.ac.uk/pdbsum/2p59 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p59 RCSB]</span>
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}}
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'''Crystal Structure of Hepatitis C Virus NS3.4A protease'''
'''Crystal Structure of Hepatitis C Virus NS3.4A protease'''
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[[Category: Perni, R B.]]
[[Category: Perni, R B.]]
[[Category: Wei, Y.]]
[[Category: Wei, Y.]]
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[[Category: hcv protease]]
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[[Category: Hcv protease]]
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[[Category: viral protein]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:23:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:29:49 2008''
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Revision as of 09:23, 4 May 2008

Image:2p59.jpg

Template:STRUCTURE 2p59

Crystal Structure of Hepatitis C Virus NS3.4A protease


Overview

Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease. Inhibition of viral replicon RNA production in Huh-7 cells has also been demonstrated. We show herein that the inclusion of hydrogen bond donors on the P4 capping group of tetrapeptide-based inhibitors result in increased binding potency to the NS3.4A protease. The capping groups also impart significant effects on the pharmacokinetic profile of these inhibitors.

About this Structure

2P59 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics., Perni RB, Chandorkar G, Cottrell KM, Gates CA, Lin C, Lin K, Luong YP, Maxwell JP, Murcko MA, Pitlik J, Rao G, Schairer WC, Van Drie J, Wei Y, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3406-11. Epub 2007 Apr 3. PMID:17482818 Page seeded by OCA on Sun May 4 12:23:32 2008

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