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2p8r
From Proteopedia
(Difference between revisions)
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==Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 carrying R2303K mutant== | ==Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 carrying R2303K mutant== | ||
| - | <StructureSection load='2p8r' size='340' side='right' caption='[[2p8r]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='2p8r' size='340' side='right'caption='[[2p8r]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2p8r]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2p8r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P8R FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prp-8 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prp-8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8r OCA], [https://pdbe.org/2p8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p8r RCSB], [https://www.ebi.ac.uk/pdbsum/2p8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8r ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PRP8_CAEEL PRP8_CAEEL]] Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Pre-mRNA | + | *[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Caeel]] | [[Category: Caeel]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Guarnieri, M T]] | [[Category: Guarnieri, M T]] | ||
[[Category: Heroux, A]] | [[Category: Heroux, A]] | ||
Revision as of 15:18, 17 June 2021
Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 carrying R2303K mutant
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Categories: Caeel | Large Structures | Guarnieri, M T | Heroux, A | Shen, J | Yang, K | Zhang, L | Zhao, R | Alpha-beta | Splicing | Translation
