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2of3

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Revision as of 12:54, 9 June 2021

TOG domain structure from C.elegans Zyg9

Structural highlights

2of3 is a 1 chain structure with sequence from Caeel. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	zyg-9 (CAEEL)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Members of the XMAP215/Dis1 family of microtubule-associated proteins (MAPs) are essential for microtubule growth. MAPs in this family contain several 250 residue repeats, called TOG domains, which are thought to bind tubulin dimers and promote microtubule polymerization. We have determined the crystal structure of a single TOG domain from the Caenorhabditis elegans homolog, Zyg9, to 1.9 A resolution, and from it we describe a structural blueprint for TOG domains. These domains are flat, paddle-like structures, composed of six HEAT-repeat elements stacked side by side. The two wide faces of the paddle contain the HEAT-repeat helices, and the two narrow faces, the intra- and inter-HEAT repeat turns. Solvent-exposed residues in the intrarepeat turns are conserved, both within a particular protein and across the XMAP215/Dis1 family. Mutation of some of these residues in the TOG1 domain from the budding yeast homolog, Stu2p, shows that this face indeed participates in the tubulin contact.

Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding.,Al-Bassam J, Larsen NA, Hyman AA, Harrison SC Structure. 2007 Mar;15(3):355-62. PMID:17355870^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Al-Bassam J, Larsen NA, Hyman AA, Harrison SC. Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding. Structure. 2007 Mar;15(3):355-62. PMID:17355870 doi:10.1016/j.str.2007.01.012

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2of3"

@@ Line 1: / Line 1: @@
 ==TOG domain structure from C.elegans Zyg9==
-<StructureSection load='2of3' size='340' side='right' caption='[[2of3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='2of3' size='340' side='right'caption='[[2of3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2of3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OF3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2of3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OF3 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">zyg-9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">zyg-9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2of3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2of3 OCA], [http://pdbe.org/2of3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2of3 RCSB], [http://www.ebi.ac.uk/pdbsum/2of3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2of3 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2of3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2of3 OCA], [https://pdbe.org/2of3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2of3 RCSB], [https://www.ebi.ac.uk/pdbsum/2of3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2of3 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 31: / Line 31: @@
 </StructureSection>
 [[Category: Caeel]]
+[[Category: Large Structures]]
 [[Category: Al-Bassam, J]]
 [[Category: Harrison, S C]]

2of3

From Proteopedia

Revision as of 12:54, 9 June 2021

TOG domain structure from C.elegans Zyg9

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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