6ae8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement== | |
| - | + | <StructureSection load='6ae8' size='340' side='right'caption='[[6ae8]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ae8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AE8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ae8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ae8 OCA], [http://pdbe.org/6ae8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ae8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ae8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ae8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[http://www.uniprot.org/uniprot/CHZ1_YEAST CHZ1_YEAST]] Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.<ref>PMID:17289584</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Shan, S]] | ||
| + | [[Category: Wang, Y Y]] | ||
| + | [[Category: Zhou, Z]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Histone variant]] | ||
Revision as of 05:50, 17 April 2019
Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement
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