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2pbi

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[[Image:2pbi.jpg|left|200px]]
[[Image:2pbi.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2pbi |SIZE=350|CAPTION= <scene name='initialview01'>2pbi</scene>, resolution 1.950&Aring;
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The line below this paragraph, containing "STRUCTURE_2pbi", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Residue+D+901'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Residue+B+902'>AC2</scene>, <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+D+903'>AC3</scene>, <scene name='pdbsite=AC4:Gol+Binding+Site+For+Residue+A+904'>AC4</scene>, <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+A+905'>AC5</scene>, <scene name='pdbsite=AC6:Gol+Binding+Site+For+Residue+A+906'>AC6</scene>, <scene name='pdbsite=AC7:Gol+Binding+Site+For+Residue+C+907'>AC7</scene>, <scene name='pdbsite=AC8:Gol+Binding+Site+For+Residue+D+908'>AC8</scene> and <scene name='pdbsite=AC9:Gol+Binding+Site+For+Residue+B+909'>AC9</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Rgs9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Gnb5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_2pbi| PDB=2pbi | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbi OCA], [http://www.ebi.ac.uk/pdbsum/2pbi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pbi RCSB]</span>
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}}
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'''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure'''
'''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure'''
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[[Category: Snyder, J T.]]
[[Category: Snyder, J T.]]
[[Category: Sondek, J.]]
[[Category: Sondek, J.]]
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[[Category: beta propeller]]
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[[Category: Beta propeller]]
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[[Category: dep domain]]
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[[Category: Dep domain]]
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[[Category: dhex domain]]
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[[Category: Dhex domain]]
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[[Category: ggl domain]]
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[[Category: Ggl domain]]
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[[Category: helix wrap]]
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[[Category: Helix wrap]]
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[[Category: rgs domain]]
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[[Category: Rgs domain]]
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[[Category: signaling protein]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:46:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:33:56 2008''
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Revision as of 09:46, 4 May 2008

Image:2pbi.jpg

Template:STRUCTURE 2pbi

The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure


Overview

Regulators of G-protein signaling (RGS) proteins enhance the intrinsic GTPase activity of G protein alpha (Galpha) subunits and are vital for proper signaling kinetics downstream of G protein-coupled receptors (GPCRs). R7 subfamily RGS proteins specifically and obligately dimerize with the atypical G protein beta5 (Gbeta5) subunit through an internal G protein gamma (Ggamma)-subunit-like (GGL) domain. Here we present the 1.95-A crystal structure of the Gbeta5-RGS9 complex, which is essential for normal visual and neuronal signal transduction. This structure reveals a canonical RGS domain that is functionally integrated within a molecular complex that is poised for integration of multiple steps during G-protein activation and deactivation.

About this Structure

2PBI is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:18204463 Page seeded by OCA on Sun May 4 12:46:54 2008

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