6hdu
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Rab38 in complex with GTP== | |
| - | + | <StructureSection load='6hdu' size='340' side='right'caption='[[6hdu]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hdu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HDU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hdu OCA], [http://pdbe.org/6hdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hdu RCSB], [http://www.ebi.ac.uk/pdbsum/6hdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hdu ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RAB38_HUMAN RAB38_HUMAN]] May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).[UniProtKB:Q8QZZ8]<ref>PMID:21255211</ref> <ref>PMID:23084991</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Khan, A R]] | ||
| + | [[Category: McGrath, E]] | ||
| + | [[Category: Waschbusch, D]] | ||
| + | [[Category: Cellular dynamic]] | ||
| + | [[Category: Membrane trafficking]] | ||
| + | [[Category: Rab small gtpase]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 15:24, 28 August 2019
Crystal structure of human Rab38 in complex with GTP
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