This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6heh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6heh" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6heh is ON HOLD until Paper Publication
+
==Structure of the catalytic domain of USP28 (insertion deleted)==
-
 
+
<StructureSection load='6heh' size='340' side='right'caption='[[6heh]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6heh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HEH FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6heh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6heh OCA], [http://pdbe.org/6heh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6heh RCSB], [http://www.ebi.ac.uk/pdbsum/6heh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6heh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/UBP28_HUMAN UBP28_HUMAN]] Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.<ref>PMID:16901786</ref> <ref>PMID:17558397</ref> <ref>PMID:17873522</ref> <ref>PMID:18662541</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Gersch, M]]
 +
[[Category: Komander, D]]
 +
[[Category: Deubiquitinase]]
 +
[[Category: Dub]]
 +
[[Category: Hydrolase]]
 +
[[Category: Isopeptidase]]
 +
[[Category: Protease]]
 +
[[Category: Ubiquitin]]
 +
[[Category: Ubiquitin-specific protease]]
 +
[[Category: Usp]]
 +
[[Category: Usp28]]

Revision as of 06:37, 27 March 2019

Structure of the catalytic domain of USP28 (insertion deleted)

PDB ID 6heh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6heh"
Personal tools