6hem
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the C-terminal domain of USP25 (748-1048)== | |
| - | + | <StructureSection load='6hem' size='340' side='right'caption='[[6hem]], [[Resolution|resolution]] 1.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hem]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HEM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hem OCA], [http://pdbe.org/6hem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hem RCSB], [http://www.ebi.ac.uk/pdbsum/6hem PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hem ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN]] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ubiquitinyl hydrolase 1]] | ||
| + | [[Category: Gersch, M]] | ||
| + | [[Category: Komander, D]] | ||
| + | [[Category: Deubiquitinase]] | ||
| + | [[Category: Dub]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Isopeptidase]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Ubiquitin]] | ||
| + | [[Category: Ubiquitin-specific protease]] | ||
| + | [[Category: Usp]] | ||
| + | [[Category: Usp25]] | ||
Revision as of 06:38, 27 March 2019
Structure of the C-terminal domain of USP25 (748-1048)
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