6heq

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'''Unreleased structure'''
 
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The entry 6heq is ON HOLD
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==Prion nanobody 484==
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<StructureSection load='6heq' size='340' side='right'caption='[[6heq]], [[Resolution|resolution]] 1.23&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6heq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HEQ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6heq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6heq OCA], [http://pdbe.org/6heq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6heq RCSB], [http://www.ebi.ac.uk/pdbsum/6heq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6heq ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Prion disorders are infectious diseases that are characterized by the conversion of the cellular prion protein PrPC into the pathogenic isoform PrPSc. Specific antibodies that interact with the cellular prion protein have been shown to inhibit this transition. Recombinant VHHs (variable domain of dromedary heavy-chain antibodies) or nanobodies are single-domain antibodies, making them the smallest antigen-binding fragments. A specific nanobody (Nb_PrP_01) was raised against mouse PrPC. A crystallization condition for this recombinant nanobody was identified using high-throughput screening. The crystals were optimized using streak-seeding and the hanging-drop method. The crystals belonged to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a=30.04, b=37.15, c=83.00 A, and diffracted to 1.23 A resolution using synchrotron radiation. The crystal structure of this specific nanobody against PrPC together with the known PrPC structure may help in understanding the PrPC/PrPSc transition mechanism.
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Authors: Soror, S.H., Abskharon, R.N., Wohlkonig, A.
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Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein.,Abskharon RN, Soror SH, Pardon E, El Hassan H, Legname G, Steyaert J, Wohlkonig A Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1644-6., doi: 10.1107/S1744309110042168. Epub 2010 Nov 26. PMID:21139215<ref>PMID:21139215</ref>
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Description: Prion nanobody 484
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Soror, S.H]]
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<div class="pdbe-citations 6heq" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Abskharon, R N]]
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[[Category: Soror, S H]]
[[Category: Wohlkonig, A]]
[[Category: Wohlkonig, A]]
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[[Category: Abskharon, R.N]]
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[[Category: Aggregation]]
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[[Category: Beta fold]]
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[[Category: Nanobody]]
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[[Category: Protein binding]]

Revision as of 07:55, 4 December 2019

Prion nanobody 484

PDB ID 6heq

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