6hgw

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m (Protected "6hgw" [edit=sysop:move=sysop])
Current revision (05:48, 7 August 2019) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6hgw is ON HOLD
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==Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine==
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<StructureSection load='6hgw' size='340' side='right'caption='[[6hgw]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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Authors: Kramer, J.S., Pogoryelov, D., Hiesinger, K., Proschak, E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hgw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HGW FirstGlance]. <br>
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Description: Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3W:2-(4-fluorophenyl)-~{N}-[(4-phenoxyphenyl)methyl]ethanamine'>G3W</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hgw OCA], [http://pdbe.org/6hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hgw RCSB], [http://www.ebi.ac.uk/pdbsum/6hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hgw ProSAT]</span></td></tr>
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[[Category: Proschak, E]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Hiesinger, K]]
[[Category: Hiesinger, K]]
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[[Category: Kramer, J S]]
[[Category: Pogoryelov, D]]
[[Category: Pogoryelov, D]]
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[[Category: Kramer, J.S]]
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[[Category: Proschak, E]]
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[[Category: Complex]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Seh]]

Current revision

Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-N-(4-phenoxybenzyl)ethanamine

PDB ID 6hgw

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