5nlg
From Proteopedia
(Difference between revisions)
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<StructureSection load='5nlg' size='340' side='right' caption='[[5nlg]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='5nlg' size='340' side='right' caption='[[5nlg]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5nlg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NLG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5nlg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NLG FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nlg OCA], [http://pdbe.org/5nlg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nlg RCSB], [http://www.ebi.ac.uk/pdbsum/5nlg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nlg ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRP5, FMI1, YMR229C, YM9959.11C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nlg OCA], [http://pdbe.org/5nlg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nlg RCSB], [http://www.ebi.ac.uk/pdbsum/5nlg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nlg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RRP5_YEAST RRP5_YEAST]] Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.<ref>PMID:8896463</ref> | [[http://www.uniprot.org/uniprot/RRP5_YEAST RRP5_YEAST]] Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.<ref>PMID:8896463</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Rrp5 is an essential factor during the ribosome biogenesis process. The protein contains a series of 12 S1 RNA-binding domains followed by a TetratricoPeptide Repeat (TPR) domain. In the past, several studies aiming at defining the function of the TPR domain have used nonequivalent Rrp5 constructs, as these protein fragments include not only the TPR module, but also three or four S1 domains. We solved the structure of the Rrp5 TPR module and demonstrated in vitro that the TPR region alone does not bind RNA, while the three S1 domains preceding the TPR module can associate with homopolymeric RNA. Finally, we tested the association of our Rrp5 constructs with several proposed interactors, in support of cryo-EM-based models. Coordinates: Atomic coordinates and structure factors have been deposited to the Protein Data Bank under the accession number 5NLG. | ||
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| + | Structural and interaction analysis of the Rrp5 C-terminal region.,Perebaskine N, Thore S, Fribourg S FEBS Open Bio. 2018 Aug 30;8(10):1605-1614. doi: 10.1002/2211-5463.12495., eCollection 2018 Oct. PMID:30338212<ref>PMID:30338212</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5nlg" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Atcc 18824]] | ||
[[Category: Fribourg, S]] | [[Category: Fribourg, S]] | ||
[[Category: Thore, S]] | [[Category: Thore, S]] | ||
[[Category: Nuclear protein]] | [[Category: Nuclear protein]] | ||
[[Category: Ribosome biogenesis 90s tpr domain]] | [[Category: Ribosome biogenesis 90s tpr domain]] | ||
Revision as of 07:06, 31 October 2018
RRP5 C-terminal domain
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