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2q9h
From Proteopedia
(Difference between revisions)
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==Crystal structure of the C73S mutant of diaminopimelate epimerase== | ==Crystal structure of the C73S mutant of diaminopimelate epimerase== | ||
| - | <StructureSection load='2q9h' size='340' side='right' caption='[[2q9h]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='2q9h' size='340' side='right'caption='[[2q9h]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2q9h]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2q9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gke|2gke]], [[2gkj|2gkj]], [[1gqz|1gqz]], [[1bwz|1bwz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gke|2gke]], [[2gkj|2gkj]], [[1gqz|1gqz]], [[1bwz|1bwz]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapF ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diaminopimelate_epimerase Diaminopimelate epimerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.7 5.1.1.7] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9h OCA], [https://pdbe.org/2q9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9h RCSB], [https://www.ebi.ac.uk/pdbsum/2q9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9h ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DAPF_HAEIN DAPF_HAEIN]] Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration.<ref>PMID:10194362</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Bacterium influenzae lehmann and neumann 1896]] | [[Category: Bacterium influenzae lehmann and neumann 1896]] | ||
[[Category: Diaminopimelate epimerase]] | [[Category: Diaminopimelate epimerase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Blanchard, J S]] | [[Category: Blanchard, J S]] | ||
[[Category: Cherney, M]] | [[Category: Cherney, M]] | ||
Revision as of 08:13, 25 June 2021
Crystal structure of the C73S mutant of diaminopimelate epimerase
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Categories: Bacterium influenzae lehmann and neumann 1896 | Diaminopimelate epimerase | Large Structures | Blanchard, J S | Cherney, M | Diaper, C M | James, M N.G | Pillai, B | Sutherland, A | Vederas, J C | Apo form has an open conformation | C73s mutant | Isomerase | Two structurally equivalent domain

