Purine nucleoside phosphorylase

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Line 22: Line 22:
**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
-
**[[1tcv]], [[1td1]], [[5cxs]] – SmPNP – ''Schistosoma masoni''<br />
+
**[[1tcv]], [[1td1]], [[5cxs]], [[5cxq]] – SmPNP – ''Schistosoma mansoni''<br />
**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
Line 46: Line 46:
**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />
**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br />
**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
-
**[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - PNP + phosphate - ''Helicobacter pylori''<br />
+
**[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - HpPNP + phosphate - ''Helicobacter pylori''<br />
 +
**[[6aqu]] – PfPNP + phosphate – ''Plasmodium falciparum''<br />
*Purine nucleoside phosphorylase complex with guanine and guanine derivatives
*Purine nucleoside phosphorylase complex with guanine and guanine derivatives
Line 71: Line 72:
**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
**[[3faz]] – SmPNP + inosine <br />
**[[3faz]] – SmPNP + inosine <br />
 +
**[[5tbv]] – SmPNP + tubercidine <br />
 +
**[[5tbt]] – SmPNP + cytidine <br />
**[[2ai2]] – bPNP + inosine derivative <br />
**[[2ai2]] – bPNP + inosine derivative <br />
**[[1z38]] – TvPNP + inosine <br />
**[[1z38]] – TvPNP + inosine <br />
**[[3uax]] – BcPNP + inosine <br />
**[[3uax]] – BcPNP + inosine <br />
-
**[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br />
+
**[[2bsx]] – PfPNP + inosine <br />
**[[1z39]] – TvPNP + deoxyinosine <br />
**[[1z39]] – TvPNP + deoxyinosine <br />
**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
**[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br />
Line 85: Line 88:
**[[2on6]] – hPNP (mutant) + transition state analog <br />
**[[2on6]] – hPNP (mutant) + transition state analog <br />
**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
-
**[[3fnq]] – SmPNP + hypoxanthine<br />
+
**[[3fnq]], [[5tbu]] – SmPNP + hypoxanthine<br />
**[[3scz]] – MtPNP + hypoxanthine<br />
**[[3scz]] – MtPNP + hypoxanthine<br />
**[[4dab]] – BsPNP + hypoxanthine<br />
**[[4dab]] – BsPNP + hypoxanthine<br />
Line 110: Line 113:
**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
**[[1z37]] – TvPNP + adenosine <br />
**[[1z37]] – TvPNP + adenosine <br />
-
**[[3e9r]] – SmPNP + adenine <br />
+
**[[3e9r]], [[5tbs]] – SmPNP + adenine <br />
**[[4dao]] – BsPNP + adenine <br />
**[[4dao]] – BsPNP + adenine <br />
**[[3f8w]] – SmPNP + adenosine <br />
**[[3f8w]] – SmPNP + adenosine <br />
Line 145: Line 148:
**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
 +
**[[6aqs]]]] – PfPNP (mutant) + inhibitor + phosphate<br />
**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
**[[3occ]] – YpPNP + inhibitor + phosphate<br />
**[[3occ]] – YpPNP + inhibitor + phosphate<br />
Line 150: Line 154:
**[[3phc]] – PfPNP + inhibitor + phosphate<br />
**[[3phc]] – PfPNP + inhibitor + phosphate<br />
**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
 +
 +
*PNP DeoD-type
 +
 +
**[[6f5a]], [[6f5i]], [[6g7x]] – HpPNP <br />
 +
**[[6f4w]], [[6f4x]], [[6f52]] – HpPNP + formycin <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:10, 29 August 2018

Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h)

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3D structures of purine nucleoside phosphorylase

Updated on 29-August-2018

References

  1. ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
  2. ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
  3. ↑ de Azevedo WF Jr, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochem Biophys Res Commun. 2003 Dec 19;312(3):767-72. PMID:14680831 doi:10.1016/j.bbrc.2003.10.190

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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