2ple

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[[Image:2ple.jpg|left|200px]]
[[Image:2ple.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ple |SIZE=350|CAPTION= <scene name='initialview01'>2ple</scene>
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The line below this paragraph, containing "STRUCTURE_2ple", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PO3:PHOSPHITE+ION'>PO3</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2ple| PDB=2ple | SCENE= }}
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|RELATEDENTRY=[[2pld|2PLD]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ple FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ple OCA], [http://www.ebi.ac.uk/pdbsum/2ple PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ple RCSB]</span>
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}}
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'''NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE'''
'''NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE'''
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[[Category: Singer, A U.]]
[[Category: Singer, A U.]]
[[Category: Yamazaki, T.]]
[[Category: Yamazaki, T.]]
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[[Category: phosphoric diester hydrolase]]
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[[Category: Phosphoric diester hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:21:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:37:33 2008''
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Revision as of 10:21, 4 May 2008

Image:2ple.jpg

Template:STRUCTURE 2ple

NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE


Overview

The solution structure of the C-terminal SH2 domain of phospholipase C-gamma 1 (PLC-gamma 1), in complex with a phosphopeptide corresponding to its Tyr-1021 high affinity binding site on the platelet-derived growth factor receptor, has been determined by nuclear magnetic resonance spectroscopy. The topology of the SH2-phosphopeptide complex is similar to previously reported Src and Lck SH2 complexes. However, the binding site for residues C-terminal to the phosphotyrosine (pTyr) is an extended groove that contacts peptide residues at the +1 to +6 positions relative to the pTyr. This striking difference from Src and Lck reflects the fact that the PLC-gamma 1 complex involves binding of a phosphopeptide with predominantly hydrophobic residues C-terminal to the pTyr and therefore serves as a prototype for a second class of SH2-phosphopeptide interactions.

About this Structure

2PLE is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide., Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD, Cell. 1994 May 6;77(3):461-72. PMID:8181064 Page seeded by OCA on Sun May 4 13:21:25 2008

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