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6hi8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The ATAD2 bromodomain in complex with compound 11== |
| - | + | <StructureSection load='6hi8' size='340' side='right'caption='[[6hi8]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hi8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HI8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G6W:2-azanyl-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]-2-methyl-propanamide'>G6W</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hi8 OCA], [http://pdbe.org/6hi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hi8 RCSB], [http://www.ebi.ac.uk/pdbsum/6hi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hi8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Caflisch, A]] | [[Category: Caflisch, A]] | ||
[[Category: Sledz, P]] | [[Category: Sledz, P]] | ||
| + | [[Category: Atad2]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Cytosolic protein]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 05:49, 16 October 2019
The ATAD2 bromodomain in complex with compound 11
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