6hib

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m (Protected "6hib" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6hib is ON HOLD until Paper Publication
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==The ATAD2 bromodomain in complex with compound 14==
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<StructureSection load='6hib' size='340' side='right' caption='[[6hib]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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Authors: Sledz, P., Caflisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hib]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HIB FirstGlance]. <br>
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Description: The ATAD2 bromodomain in complex with compound 14
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G6Z:1-azanyl-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]cyclobutane-1-carboxamide'>G6Z</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hib OCA], [http://pdbe.org/6hib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hib RCSB], [http://www.ebi.ac.uk/pdbsum/6hib PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hib ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
[[Category: Sledz, P]]
[[Category: Sledz, P]]
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[[Category: Atad2]]
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[[Category: Bromodomain]]
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[[Category: Complex]]
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[[Category: Cytosolic protein]]
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[[Category: Inhibitor]]

Revision as of 06:44, 21 February 2019

The ATAD2 bromodomain in complex with compound 14

6hib, resolution 2.03Å

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