2pm7

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[[Image:2pm7.jpg|left|200px]]
[[Image:2pm7.jpg|left|200px]]
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{{Structure
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|PDB= 2pm7 |SIZE=350|CAPTION= <scene name='initialview01'>2pm7</scene>, resolution 2.350&Aring;
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The line below this paragraph, containing "STRUCTURE_2pm7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= WEB1, SEC31 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SEC13, ANU3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_2pm7| PDB=2pm7 | SCENE= }}
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|RELATEDENTRY=[[2pm6|2PM6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pm7 OCA], [http://www.ebi.ac.uk/pdbsum/2pm7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pm7 RCSB]</span>
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}}
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'''Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version'''
'''Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version'''
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[[Category: Goldberg, J.]]
[[Category: Goldberg, J.]]
[[Category: Mancias, J D.]]
[[Category: Mancias, J D.]]
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[[Category: alpha solenoid]]
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[[Category: Alpha solenoid]]
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[[Category: beta propeller]]
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[[Category: Beta propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:24:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:37:51 2008''
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Revision as of 10:24, 4 May 2008

Image:2pm7.jpg

Template:STRUCTURE 2pm7

Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version


Overview

COPII-coated vesicles export newly synthesized proteins from the endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1 complex that selects cargo and the Sec13/31 assembly unit that can polymerize into an octahedral cage and deform the membrane into a bud. Crystallographic analysis of the assembly unit reveals a 28 nm long rod comprising a central alpha-solenoid dimer capped by two beta-propeller domains at each end. We construct a molecular model of the COPII cage by fitting Sec13/31 crystal structures into a recently determined electron microscopy density map. The vertex geometry involves four copies of the Sec31 beta-propeller that converge through their axial ends; there is no interdigitation of assembly units of the kind seen in clathrin cages. We also propose that the assembly unit has a central hinge-an arrangement of interlocked alpha-solenoids-about which it can bend to adapt to cages of variable curvature.

About this Structure

2PM7 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and organization of coat proteins in the COPII cage., Fath S, Mancias JD, Bi X, Goldberg J, Cell. 2007 Jun 29;129(7):1325-36. PMID:17604721 Page seeded by OCA on Sun May 4 13:24:12 2008

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