2pmi

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[[Image:2pmi.jpg|left|200px]]
[[Image:2pmi.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2pmi |SIZE=350|CAPTION= <scene name='initialview01'>2pmi</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2pmi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SAP:ADENOSINE-5&#39;-DIPHOSPHATE+MONOTHIOPHOSPHATE'>SAP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PHO85, SSG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), PHO80, AGS3, TUP7, VAC5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_2pmi| PDB=2pmi | SCENE= }}
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|RELATEDENTRY=[[2pk9|2PK9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pmi OCA], [http://www.ebi.ac.uk/pdbsum/2pmi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pmi RCSB]</span>
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}}
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'''Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S'''
'''Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S'''
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[[Category: Shea, E K.O.]]
[[Category: Shea, E K.O.]]
[[Category: Zhang, W.]]
[[Category: Zhang, W.]]
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[[Category: cyclin]]
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[[Category: Cyclin]]
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[[Category: cyclin-dependent kinase]]
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[[Category: Cyclin-dependent kinase]]
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[[Category: signaling protein,transferase/cell cycle complex]]
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[[Category: Signaling protein,transferase/cell cycle complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:25:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:38:04 2008''
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Revision as of 10:25, 4 May 2008

Image:2pmi.jpg

Template:STRUCTURE 2pmi

Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S


Overview

The ability to sense and respond appropriately to environmental changes is a primary requirement of all living organisms. In response to phosphate limitation, Saccharomyces cerevisiae induces transcription of a set of genes involved in the regulation of phosphate acquisition from the ambient environment. A signal transduction pathway (the PHO pathway) mediates this response, with Pho85-Pho80 playing a vital role. Here we report the X-ray structure of Pho85-Pho80, a prototypic structure of a CDK-cyclin complex functioning in transcriptional regulation in response to environmental changes. The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition. It further showed two sites on the Pho80 cyclin for high-affinity binding of the transcription factor substrate (Pho4) and the CDK inhibitor (Pho81) that are markedly distant to each other and the active site.

About this Structure

2PMI is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway., Huang K, Ferrin-O'Connell I, Zhang W, Leonard GA, O'Shea EK, Quiocho FA, Mol Cell. 2007 Nov 30;28(4):614-23. PMID:18042456 Page seeded by OCA on Sun May 4 13:25:01 2008

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