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2qz5
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the C-terminal domain of Aida== | ==Crystal Structure of the C-terminal domain of Aida== | ||
| - | <StructureSection load='2qz5' size='340' side='right' caption='[[2qz5]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='2qz5' size='340' side='right'caption='[[2qz5]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2qz5]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2qz5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZ5 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ug7|1ug7]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ug7|1ug7]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aida ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aida ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qz5 OCA], [https://pdbe.org/2qz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2qz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qz5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/AIDA_MOUSE AIDA_MOUSE]] Acts as a ventralizing factor during embryogenesis (By similarity). Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Zheng, L S]] | [[Category: Zheng, L S]] | ||
Revision as of 04:09, 2 July 2021
Crystal Structure of the C-terminal domain of Aida
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