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2ra4

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==Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)==
==Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)==
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<StructureSection load='2ra4' size='340' side='right' caption='[[2ra4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='2ra4' size='340' side='right'caption='[[2ra4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ra4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RA4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ra4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RA4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL13, MCP4, NCC1, SCYA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL13, MCP4, NCC1, SCYA13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ra4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra4 OCA], [http://pdbe.org/2ra4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ra4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ra4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ra4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ra4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra4 OCA], [https://pdbe.org/2ra4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ra4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ra4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ra4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CCL13_HUMAN CCL13_HUMAN]] Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
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[[https://www.uniprot.org/uniprot/CCL13_HUMAN CCL13_HUMAN]] Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
*[[Multiple sclerosis|Multiple sclerosis]]
*[[Multiple sclerosis|Multiple sclerosis]]
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*[[User:Coline Perrin/CCL2|User:Coline Perrin/CCL2]]
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Barinka, C]]
[[Category: Barinka, C]]
[[Category: Lubkowski, J]]
[[Category: Lubkowski, J]]

Revision as of 04:19, 2 July 2021

Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)

PDB ID 2ra4

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