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Rho GTPase

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Line 36: Line 36:
**[[3kz1]] – hRhoA + guanine nucleotide exchange factor 11 + GSP<br />
**[[3kz1]] – hRhoA + guanine nucleotide exchange factor 11 + GSP<br />
**[[1x86]] – hRhoA + guanine nucleotide exchange factor 12<br />
**[[1x86]] – hRhoA + guanine nucleotide exchange factor 12<br />
 +
**[[6bcb]] – hRhoA + guanine nucleotide exchange factor 18<br />
 +
**[[6bc0]] – hRhoA + guanine nucleotide exchange factor 28 + GTP analog<br />
*RhoA complex with Rho GTPase-activating protein
*RhoA complex with Rho GTPase-activating protein
Line 55: Line 57:
**[[4xoi]] – hRhoA (mutant) + actin-binding protein anillin + GTP <br />
**[[4xoi]] – hRhoA (mutant) + actin-binding protein anillin + GTP <br />
**[[4f38]] – mRhoA + Rho GDP-dissociation inhibitor 1 + GPPNP <br />
**[[4f38]] – mRhoA + Rho GDP-dissociation inhibitor 1 + GPPNP <br />
-
**[[4d0n]] – hRhoA + A-kinase anchor protein 13 + GDP<br />
+
**[[4d0n]], [[6bca]] – hRhoA + A-kinase anchor protein 13 + GDP<br />
**[[3lw8]], [[3lwn]], [[3lxr]] – hRhoA + IpgB2 + GDP<br />
**[[3lw8]], [[3lwn]], [[3lxr]] – hRhoA + IpgB2 + GDP<br />
**[[1s1c]] – hRhoA + ROCKI + GNP<br />
**[[1s1c]] – hRhoA + ROCKI + GNP<br />
Line 63: Line 65:
**[[5c2k]] – hRhoA/Rac GTPase-activating protein 1 + GDP <br />
**[[5c2k]] – hRhoA/Rac GTPase-activating protein 1 + GDP <br />
**[[5jcp]] – hRhoA/ARAP3 + GDP <br />
**[[5jcp]] – hRhoA/ARAP3 + GDP <br />
 +
**[[5zhx]] – hRhoA (mutant) + RAP1 <br />
*RhoB
*RhoB

Revision as of 09:40, 6 September 2018

Human RhoA (magenta) complex with RhoGAP (cyan), GDP, AlF4 and Mg+2 ion (green) (PDB code 1tx4)

Drag the structure with the mouse to rotate

3D structures of Rho GTPase

Updated on 06-September-2018

References

  1. ↑ Sepp KJ, Auld VJ. RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development. 2003 May;130(9):1825-35. PMID:12642488
  2. ↑ Fransson A, Ruusala A, Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem. 2003 Feb 21;278(8):6495-502. Epub 2002 Dec 12. PMID:12482879 doi:http://dx.doi.org/10.1074/jbc.M208609200
  3. ↑ Zhou J, Hayakawa Y, Wang TC, Bass AJ. RhoA mutations identified in diffuse gastric cancer. Cancer Cell. 2014 Jul 14;26(1):9-11. doi: 10.1016/j.ccr.2014.06.022. PMID:25026207 doi:http://dx.doi.org/10.1016/j.ccr.2014.06.022
  4. ↑ Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci (Lond). 2006 Feb;110(2):153-65. PMID:16411892 doi:http://dx.doi.org/10.1042/CS20050255
  5. ↑ Rittinger K, Walker PA, Eccleston JF, Smerdon SJ, Gamblin SJ. Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature. 1997 Oct 16;389(6652):758-62. PMID:9338791 doi:10.1038/39651

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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