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2psm

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[[Image:2psm.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2psm", creates the "Structure Box" on the page.
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|GENE= Il15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Il15ra ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_2psm| PDB=2psm | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2psm OCA], [http://www.ebi.ac.uk/pdbsum/2psm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2psm RCSB]</span>
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'''Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha'''
'''Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha'''
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Revision as of 10:44, 4 May 2008

Image:2psm.jpg


PDB ID 2psm

Drag the structure with the mouse to rotate
2psm, resolution 2.19Å ()
Ligands:
Gene: Il15 (Mus musculus), Il15ra (Mus musculus)
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha


Overview

Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans signaling mechanism in which IL-15 receptor alpha (IL-15Ralpha) from one subset of cells presents IL-15 to neighboring IL-2Rbeta/gammac-expressing cells. Here we present the crystal structure of IL-15 in complex with the sushi domain of IL-15Ralpha. The structure reveals that the alpha receptor-binding epitope of IL-15 adopts a unique conformation, which, together with amino acid substitutions, permits specific interactions with IL-15Ralpha that account for the exceptionally high affinity of the IL-15.IL-15Ralpha complex. Interestingly, analysis of the topology of IL-15 and IL-15Ralpha at the IL-15.IL-15Ralpha interface suggests that IL-15 should be capable of participating in a cis signaling mechanism similar to that of the related cytokine IL-2. Indeed, we present biochemical data demonstrating that IL-15 is capable of efficiently signaling in cis through IL-15Ralpha and IL-2Rbeta/gammac expressed on the surface of a single cell. Based on our data we propose that cis presentation of IL-15 may be important in certain biological contexts and that flexibility of IL-15Ralpha permits IL-15 and its three receptor components to be assembled identically at the ligand-receptor interface whether IL-15 is presented in cis or trans. Finally, we have gained insights into IL-15.IL-15Ralpha.IL-2Rbeta.gammac quaternary complex assembly through the use of molecular modeling.

About this Structure

2PSM is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation., Olsen SK, Ota N, Kishishita S, Kukimoto-Niino M, Murayama K, Uchiyama H, Toyama M, Terada T, Shirouzu M, Kanagawa O, Yokoyama S, J Biol Chem. 2007 Dec 21;282(51):37191-204. Epub 2007 Oct 18. PMID:17947230 Page seeded by OCA on Sun May 4 13:44:05 2008

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