6mdm

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m (Protected "6mdm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6mdm is ON HOLD
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==The 20S supercomplex engaging the SNAP-25 N-terminus (class 1)==
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<StructureSection load='6mdm' size='340' side='right' caption='[[6mdm]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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Authors: White, K.I., Zhao, M., Brunger, A.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mdm]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MDM FirstGlance]. <br>
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Description: The 20S supercomplex engaging the SNAP-25 N-terminus (class 1)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr>
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[[Category: White, K.I]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mdm OCA], [http://pdbe.org/6mdm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mdm RCSB], [http://www.ebi.ac.uk/pdbsum/6mdm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mdm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/NSF_CRIGR NSF_CRIGR]] Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling. [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/SNAA_RAT SNAA_RAT]] Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
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__TOC__
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</StructureSection>
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[[Category: Vesicle-fusing ATPase]]
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[[Category: Brunger, A T]]
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[[Category: White, K I]]
[[Category: Zhao, M]]
[[Category: Zhao, M]]
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[[Category: Brunger, A.T]]
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[[Category: Aaa]]
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[[Category: Atpase]]
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[[Category: Disassembly]]
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[[Category: Exocytosis]]
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[[Category: Hydrolase]]
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[[Category: Membrane fusion]]
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[[Category: Nsf]]
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[[Category: Snap]]
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[[Category: Snare]]
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[[Category: Synapse]]

Revision as of 20:00, 19 September 2018

The 20S supercomplex engaging the SNAP-25 N-terminus (class 1)

6mdm, resolution 4.40Å

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