2pv6
From Proteopedia
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'''HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle''' | '''HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle''' | ||
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[[Category: Sun, Z Y.J.]] | [[Category: Sun, Z Y.J.]] | ||
[[Category: Wagner, G.]] | [[Category: Wagner, G.]] | ||
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Revision as of 10:51, 4 May 2008
HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle
Overview
Although rarely elicited during natural human infection, the most broadly neutralizing antibodies (BNAbs) against diverse human immunodeficiency virus (HIV)-1 strains target the membrane-proximal ectodomain region (MPER) of viral gp41. To gain insight into MPER antigenicity, immunogenicity, and viral function, we studied its structure in the lipid environment by a combination of nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), and surface plasmon resonance (SPR) techniques. The analyses revealed a tilted N-terminal alpha helix (aa 664-672) connected via a short hinge to a flat C-terminal helical segment (675-683). This metastable L-shaped structure is immersed in viral membrane and, therefore, less accessible to immune attack. Nonetheless, the 4E10 BNAb extracts buried W672 and F673 after initial encounter with the surface-embedded MPER. The data suggest how BNAbs may perturb tryptophan residue-associated viral fusion involving the mobile N-terminal MPER segment and, given conservation of MPER sequences in HIV-1, HIV-2, and SIV, have important implications for structure-guided vaccine design.
About this Structure
2PV6 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane., Sun ZY, Oh KJ, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang JH, Wagner G, Reinherz EL, Immunity. 2008 Jan;28(1):52-63. PMID:18191596 Page seeded by OCA on Sun May 4 13:51:27 2008
