2pz5

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[[Image:2pz5.jpg|left|200px]]
[[Image:2pz5.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2pz5 |SIZE=350|CAPTION= <scene name='initialview01'>2pz5</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_2pz5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ABG:ADENOSINE+5&#39;-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE'>ABG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FGFR2, BEK, KSAM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2pz5| PDB=2pz5 | SCENE= }}
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|RELATEDENTRY=[[2psq|2PSQ]], [[2pvf|2PVF]], [[2pvy|2PVY]], [[2pwl|2PWL]], [[2py3|2PY3]], [[2pzp|2PZP]], [[2pzr|2PZR]], [[2q0b|2Q0B]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pz5 OCA], [http://www.ebi.ac.uk/pdbsum/2pz5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pz5 RCSB]</span>
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}}
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'''Crystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome'''
'''Crystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome'''
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[[Category: Chen, H.]]
[[Category: Chen, H.]]
[[Category: Mohammadi, M.]]
[[Category: Mohammadi, M.]]
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[[Category: kinase domain fold consisting of n- and c-lobe]]
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[[Category: Kinase domain fold consisting of n- and c-lobe]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:03:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:42:40 2008''
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Revision as of 11:03, 4 May 2008

Image:2pz5.jpg

Template:STRUCTURE 2pz5

Crystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome


Overview

Activating mutations in the tyrosine kinase domain of receptor tyrosine kinases (RTKs) cause cancer and skeletal disorders. Comparison of the crystal structures of unphosphorylated and phosphorylated wild-type FGFR2 kinase domains with those of seven unphosphorylated pathogenic mutants reveals an autoinhibitory "molecular brake" mediated by a triad of residues in the kinase hinge region of all FGFRs. Structural analysis shows that many other RTKs, including PDGFRs, VEGFRs, KIT, CSF1R, FLT3, TEK, and TIE, are also subject to regulation by this brake. Pathogenic mutations activate FGFRs and other RTKs by disengaging the brake either directly or indirectly.

About this Structure

2PZ5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases., Chen H, Ma J, Li W, Eliseenkova AV, Xu C, Neubert TA, Miller WT, Mohammadi M, Mol Cell. 2007 Sep 7;27(5):717-30. PMID:17803937 Page seeded by OCA on Sun May 4 14:03:02 2008

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OCA

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