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6me3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin== | |
| - | + | <StructureSection load='6me3' size='340' side='right'caption='[[6me3]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6me3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ME3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ME3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JEY:N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide'>JEY</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6me3 OCA], [http://pdbe.org/6me3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6me3 RCSB], [http://www.ebi.ac.uk/pdbsum/6me3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6me3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MTR1A_HUMAN MTR1A_HUMAN]] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Batyuk, A]] | ||
| + | [[Category: Brehm, W]] | ||
| + | [[Category: Cherezov, V]] | ||
| + | [[Category: Gati, C]] | ||
| + | [[Category: Grandner, J M]] | ||
| + | [[Category: Grant, T D]] | ||
| + | [[Category: Han, G W]] | ||
| + | [[Category: Ishchenko, A]] | ||
| + | [[Category: Johansson, L C]] | ||
| + | [[Category: Katritch, V]] | ||
| + | [[Category: Liu, W]] | ||
| + | [[Category: Madsen, C]] | ||
| + | [[Category: McCorvy, J D]] | ||
| + | [[Category: Michaelian, N]] | ||
| + | [[Category: Olsen, R H.J]] | ||
| + | [[Category: Patel, N]] | ||
| + | [[Category: Roth, B L]] | ||
| + | [[Category: Stauch, B]] | ||
| + | [[Category: Tribo, A R]] | ||
| + | [[Category: Weierstall, U]] | ||
| + | [[Category: White, T A]] | ||
| + | [[Category: Zhu, L]] | ||
| + | [[Category: 2-phenylmelatonin]] | ||
| + | [[Category: Circadian rhythm]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Jetlag]] | ||
| + | [[Category: Lcp]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Pg]] | ||
| + | [[Category: Xfel]] | ||
Revision as of 06:57, 24 April 2019
XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin
| |||||||||||
Categories: Large Structures | Batyuk, A | Brehm, W | Cherezov, V | Gati, C | Grandner, J M | Grant, T D | Han, G W | Ishchenko, A | Johansson, L C | Katritch, V | Liu, W | Madsen, C | McCorvy, J D | Michaelian, N | Olsen, R H.J | Patel, N | Roth, B L | Stauch, B | Tribo, A R | Weierstall, U | White, T A | Zhu, L | 2-phenylmelatonin | Circadian rhythm | Gpcr | Jetlag | Lcp | Membrane protein | Pg | Xfel
