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2q7f

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[[Image:2q7f.jpg|left|200px]]
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{{Structure
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|GENE= yrrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7f OCA], [http://www.ebi.ac.uk/pdbsum/2q7f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q7f RCSB]</span>
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'''Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site'''
'''Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site'''
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[[Category: Lim, H.]]
[[Category: Lim, H.]]
[[Category: Oh, J.]]
[[Category: Oh, J.]]
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[[Category: protein binding]]
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[[Category: Protein binding]]
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[[Category: tpr]]
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[[Category: Tpr]]
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[[Category: yrrb]]
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[[Category: Yrrb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:28:52 2008''
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Revision as of 11:28, 4 May 2008

Image:2q7f.jpg

Template:STRUCTURE 2q7f

Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site


Overview

YrrB is a hypothetical protein containing a tetratricopeptide repeat (TPR) domain from a Gram-positive bacterium, Bacillus subtilis. We determined YrrB structure in the C2 space group to 2.5A resolution, which is the first TPR structure of the Gram-positive bacterium B. subtilis. In contrast to other known TPR structures, the concave surface of the YrrB TPR domain is composed of the putative peptide-binding pocket lined with positively-charged residues. This unique charge distribution reveals that YrrB can interact with partner proteins via an unusual TPR-mediated interaction mode, compared to that of other TPR-containing structures. Functional annotation using genomics analysis suggested that YrrB may be an interacting mediator in the complex formation among RNA sulfuration components. No proteins containing a TPR domain have been identified in the biosynthesis of sulfur-containing biomolecules. Thus, YrrB could play a new role as a connecting module among those proteins in the conserved gene cluster for RNA sulfuration.

About this Structure

2Q7F is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site., Han D, Oh J, Kim K, Lim H, Kim Y, Biochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5. PMID:17624311 Page seeded by OCA on Sun May 4 14:28:52 2008

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